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However, in human glioblastoma cells and normal astrocytes, p53 can promote MVP by inducing a group of related enzymes including 3′-hydroxy-3′-methylglutaryl-coenzyme A reductase (HMGCR), mevalonate kinase (MVK), farnesyl diphosphate synthase (FDPS) and farnesyl diphosphate farnesyl transferase 1 (FDFT1) [99]. prediksi 99 kamboja